That depends on what you plan to do. If you are planning to stick with the convention activities, then probably not. We will provide transportation to most convention activities and venues (See individual event descriptions for details). One exception will be the self-guided layout tours which, by definition, will require attendees to arrange their own transportation. However, most layout tours will provide bus transportation.
Of course, if you plan to go off doing your own activities during the convention, then a car might be necessary. Portland has an excellent mass transit system, including its MAX Light Rail system that has a stop right at the hotel. Most popular destinations within the city that you might want to visit on your own can be easily reached using MAX, street car or buses.